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ARVO 2019

Posted 3/18/2019

2019 Association for Research in Vision and Ophthalmology (ARVO)

"Longitudinal Analysis of Metamorphopsia Measurement  and its Relation to Change in Drusen Size and Volume in Intermediate Age-Related Macular Degeneration"


To compare the development of metamorphopsia versus drusen size and drusen volume in eyes with intermediate age-related macular degeneration (AMD).

METHODS: In a clinical practice setup, subjects with intermediate age-related macular degeneration (iAMD) were available for this study between August 2015 and November 2018. Metamorphopsia Index (MI) consisting of magnitude (d), excentricity (ε) and area (a) was measured with AMD – A Metamorphopsia Detector®. Elevation in retinal pigment epithelium indicating drusen was quantified with the advanced RPE analysis tool (Cirrus, Carl Zeiss Meditec®) in a 5 mm diameter centered on the fovea (area and volume) at study inclusion and ≥ 6 months later. Changes over time were intra-individually compared using dependent samples t-test. Follow up was terminated when eyes developed late AMD. All patients signed informed consent according to the declaration of Helsinki prior to the study.


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